PHARMACEUTICAL ORAL SOLID DOSAGE PROCESS SCIENTIST

PHARMACEUTICAL ORAL SOLID DOSAGE PROCESS SCIENTIST Location: Jeddah, Saudi Arabia Employment type: Full-time Workplace: On-site Indicative salary: SAR 17,000–26,000 per month 𝐇𝐈𝐆𝐇𝐋𝐘 𝐓𝐄𝐂𝐇𝐍𝐈𝐂𝐀𝐋 𝐎𝐑𝐀𝐋 𝐒𝐎𝐋𝐈𝐃 𝐃𝐎𝐒𝐀𝐆𝐄 𝐑𝐎𝐋𝐄 Candidates should have substantial hands-on experience with tablet, capsule or oral-solid manufacturing processes, preferably including granulation, blending, milling, compression, coating or process troubleshooting. This is not a general QA, regulatory or commercial position. We are looking for a pharmaceutical scientist or engineer who understands how material properties, formulation parameters, equipment settings and manufacturing conditions interact throughout the oral-solid production process. 𝐀𝐛𝐨𝐮𝐭 𝐭𝐡𝐞 𝐫𝐨𝐥𝐞 Palomba General Trading LLC is looking for a Pharmaceutical Oral Solid Dosage Process Scientist to support technically demanding pharmaceutical manufacturing projects in Saudi Arabia and the wider GCC. The role will focus on the industrial processing of tablets, capsules, powders and granules, with particular attention to process robustness, equipment performance and troubleshooting. The successful candidate will work across formulation, manufacturing, engineering and technical project teams to improve product consistency and manufacturing performance. The role may involve both existing production lines and new manufacturing projects. 𝐊𝐞𝐲 𝐓𝐞𝐜𝐡𝐧𝐢𝐜𝐚𝐥 𝐑𝐞𝐬𝐩𝐨𝐧𝐬𝐢𝐛𝐢𝐥𝐢𝐭𝐢𝐞𝐬 • Evaluate oral-solid manufacturing processes from raw-material preparation through finished dosage form. • Support optimisation of powder blending. • Evaluate granulation processes. • Review wet and dry granulation parameters. • Support milling and particle-size-control activities. • Analyse powder flow and blend uniformity. • Review lubricant addition and final blending. • Support tablet-compression optimisation. • Analyse compression-force requirements. • Investigate tablet-weight variability. • Evaluate hardness and friability issues. • Support capsule-filling processes where applicable. • Review coating-process parameters. • Support troubleshooting of coating defects. • Evaluate process yield and product loss. • Investigate segregation during transfer. • Analyse batch-to-batch variability. • Support scale-up and process-transfer activities. • Review process parameters during pilot and commercial batches. • Support manufacturing trials. • Participate in root-cause investigations. • Work with engineering teams where equipment performance contributes to manufacturing problems. 𝐏𝐨𝐰𝐝𝐞𝐫 & 𝐆𝐫𝐚𝐧𝐮𝐥𝐚𝐭𝐢𝐨𝐧 𝐒𝐜𝐢𝐞𝐧𝐜𝐞 Candidates should understand parameters such as: • Particle-size distribution • Bulk density • Tapped density • Flowability • Compressibility • Moisture content • Granule strength • Binder concentration • Liquid addition rate • Mixing time • Impeller speed • Chopper speed • Endpoint determination • Drying conditions • Final moisture 𝐁𝐥𝐞𝐧𝐝𝐢𝐧𝐠 & 𝐂𝐨𝐧𝐭𝐞𝐧𝐭 𝐔𝐧𝐢𝐟𝐨𝐫𝐦𝐢𝐭𝐲 The role may include: • Blend-time optimisation • Low-dose API distribution • Segregation-risk assessment • Excipient distribution • Lubrication optimisation • Sampling strategies • Blend-uniformity troubleshooting • Powder-transfer assessment 𝐓𝐚𝐛𝐥𝐞𝐭 𝐂𝐨𝐦𝐩𝐫𝐞𝐬𝐬𝐢𝐨𝐧 Relevant parameters may include: • Compression force • Pre-compression • Main compression • Turret speed • Fill depth • Tablet weight • Hardness • Thickness • Friability • Disintegration • Ejection force Candidates should be capable of investigating manufacturing defects such as: • Capping • Lamination • Sticking • Picking • Weight variation • Excessive friability • Poor hardness • Slow disintegration 𝐂𝐨𝐚𝐭𝐢𝐧𝐠 𝐏𝐫𝐨𝐜𝐞𝐬𝐬𝐞𝐬 Experience may include: • Film coating • Functional coating • Enteric coating • Spray-rate optimisation • Atomisation • Inlet-air temperature • Exhaust temperature • Bed temperature • Pan speed • Drying conditions The candidate may troubleshoot: • mottling; • roughness; • peeling; • twinning; • sticking; • uneven coating; • colour variation. 𝐂𝐚𝐩𝐬𝐮𝐥𝐞 𝐀𝐩𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧𝐬 Relevant experience may include: • Powder filling • Granule filling • Fill-weight control • Flow problems • Dosing-disc systems • Tamping systems • Capsule closing • In-process controls 𝐏𝐫𝐨𝐜𝐞𝐬𝐬 𝐄𝐪𝐮𝐢𝐩𝐦𝐞𝐧𝐭 Candidates may have worked with: • High-shear granulators • Fluid-bed processors • Roller compactors • Mills • Sieves • Bin blenders • V-blenders • IBC systems • Tablet presses • Capsule fillers • Coating pans • Vacuum-transfer systems • Contained powder-transfer systems 𝐓𝐫&

Substantial hands-on experience with tablet, capsule or oral-solid manufacturing processes, preferably including granulation, blending, milling, compression, coating or process troubleshooting. Understands how material properties, formulation parameters, equipment settings and manufacturing conditions interact throughout the oral-solid production process.

Evaluate oral-solid manufacturing processes from raw-material preparation through finished dosage form. Support optimisation of powder blending. Evaluate granulation processes. Review wet and dry granulation parameters. Support milling and particle-size-control activities. Analyse powder flow and blend uniformity. Review lubricant addition and final blending. Support tablet-compression optimisation. Analyse compression-force requirements. Investigate tablet-weight variability. Evaluate hardness and friability issues. Support capsule-filling processes where applicable. Review coating-process parameters. Support troubleshooting of coating defects. Evaluate process yield and product loss. Investigate segregation during transfer. Analyse batch-to-batch variability. Support scale-up and process-transfer activities. Review process parameters during pilot and commercial batches. Support manufacturing trials. Participate in root-cause investigations. Work with engineering teams where equipment performance contributes to manufacturing problems.